Bioavailability & It’s Role In Optimal Health


What is Bioavailability?

Picture this—you just sat down to eat a bright, colorful salad made with loads of leafy greens, lots of fresh vegetables, topped off with walnuts, avocado, and a homemade salad dressing.

Making healthy, plant-based eating a priority is great, but…

There may be one important consideration that has been left out. As the old saying goes “you are what you eat”, but we respectfully disagree.

You are not necessarily what you eat, you are what you assimilate. And in order to assimilate nutrients or absorb and utilize them, they need to be bioavailable.

Bioavailability can be defined as the amount of a nutrient that is absorbed from the small intestine (the major site of absorption in the digestive tract) into the bloodstream, where it is transported to cells that need it or stored for later use.

Why do we care?

Just because you consume various nutrients, doesn’t mean that 100% of them make their way to your bloodstream and the cells that need them.

Until a nutrient passes from the digestive system into the bloodstream, it basically has little or no value.

Bioavailability of Macronutrients Versus Micronutrients

Nutrients can be broken down into two categories: macronutrients and micronutrients. Macronutrients provide the body with calories and are needed in larger quantities. There are three macronutrients: carbohydrates, proteins, and fats.

The bioavailability of macronutrients is usually very high—about 90% or more is absorbed into the bloodstream and utilized by the body. In order to become bioavailable, macronutrients need to be digested and broken down into smaller components. Carbohydrates are broken down into glucose (simple sugars), proteins into amino acids, and fats into fatty acids and glycerol.

Micronutrients on the other hand, are needed in smaller quantities and are things like vitamins, minerals, and phytochemicals (to learn more about phytochemicals, take a look at our previous blog articles on sprouts!). Although we need less micronutrients, this has no bearing on their importance—they are vital for life and have a major impact on our health.

The bioavailability of micronutrients can vary greatly, meaning that they vary in the extent to which they are absorbed and utilized by the body.

What Factors Affect Bioavailability?

Bioavailability is a complex process that involves several phases including liberation (digestion), absorption, distribution, metabolism, and elimination.

At any point in time during these phases, a change in nutrient bioavailability may occur. There are also additional factors outside of these phases that affect the bioavailability of a nutrient. We will discuss the main factors that impact a nutrient’s bioavailability.

I. Digestion

The first step to making a nutrient bioavailable is to break it down or “liberate” it from its food matrix so that it is in a form that is absorbable. This is defined as bioaccessibility.

How exactly does this work?

The digestive organs of interest here are the mouth, stomach, and small intestine. In order to fully digest our food, we must:

  1. Chew the food well; digestive enzymes secreted by the salivary glands also mix with the food to help break it down.
  2. The food is further broken down by the strong muscles of the stomach, which mix the food with hydrochloric acid and digestive enzymes; this turns the food into a liquid paste called chyme.
  3. The chyme enters the small intestine, where it is broken down even further by pancreatic digestive enzymes and bile; adequately digested nutrients are then absorbed through the lining of the small intestine into the bloodstream.

If nutrients are not absorbed, they will pass through the small intestine into the large intestine, where they will eventually be excreted through the feces.

II. Enhancers Versus Inhibitors

At the site of absorption in the small intestine, nutrients may interact with one another or other dietary components, which may lead to a change in bioavailability. Enhancers are factors that increase bioavailability, whereas inhibitors decrease bioavailability. It is possible for enhancers and inhibitors to cancel each other out, resulting in a nutrient that is unable to be absorbed and utilized by the body.


  • · The presence of some micronutrients may enhance the absorption of others:
    • Vitamin C improves absorption of nonheme iron (iron found in plant-based sources)
    • Vitamin D improves absorption of calcium, phosphorous, and magnesium
  • · Adding fat to a meal may enhance bioavailability:
    • Carotenoids are fat-soluble and need a small amount of fat or oil added to the meal to improve their bioavailability


  • The presence of some micronutrients may inhibit the absorption of others:
    •  High levels of Zinc decrease the absorption of iron and copper
  • The presence of absorption inhibitors (also known as anti-nutrients)
    •  Phytates found in plant foods (legumes, grains, edible seeds, and nuts) block the absorption of some minerals including calcium, zinc, iron, magnesium, and manganese
    • Oxalates found in plant foods (spinach, coffee, berries, etc.) block the absorption of some minerals including calcium, zinc, and iron

The good news is that there are ways to reduce phytates in plant foods. For instance, sprouting grains, edible seeds, nuts, and legumes significantly decreases their phytic acid content. This makes the food easier to digest and also allows for enhanced absorption of the minerals present in these foods.

III. Individual Variability

When nutrients are digested, the amount that becomes absorbed and eventually used by your cells depends on your body’s needs, which is largely individualized. The rate and amount of absorption that takes place varies widely among different people and are impacted by factors such as:

  • Age
  • Sex
  • Genetic background
  • Health status
    • Presence of chronic diseases, especially of the digestive tract
    • Inflammatory condition or infections (may reduce the gut’s ability to absorb certain nutrients)
  • Level of nutrients already present in your body
  • Diet
  • Gut microbiome composition
  • Pharmaceutical drugs (some drugs may interfere with absorption of nutrients, such as minerals)


Bioavailability is the key to getting the most nutrition out of the food that we eat.

We can eat all the healthy food we want, but if we are unable to absorb and utilize the food’s nutrients, then it doesn’t do our bodies any good.

Bioavailability is also a determinant of whether a person is able to reach a state of optimal health—which is what we are all striving for at the end of the day, right?



  1. The European Food Information Council. “Nutrient bioavailability: Getting the most out of food.” EUFIC, 1 Dec 2010, article/nutrient-bioavailability-getting-the-most-out-of-food
  2. Marze, Sébastien. "Bioavailability of nutrients and micronutrients: Advances in modeling and in vitro approaches." Annual review of food science and technology 8 (2017): 35-55.
  3. Karaś, Monika, et al. "Digestion and bioavailability of bioactive phytochemicals." International Journal of Food Science & Technology 52.2 (2017): 291-305.
  4. Rein, Maarit J., et al. "Bioavailability of bioactive food compounds: a challenging journey to bioefficacy." British journal of clinical pharmacology 75.3 (2013): 588-602.
  5. Schönfeldt, Hester Carina, Beulah Pretorius, and Nicolette Hall. "Bioavailability of nutrients." Caballero, B, P Finglas and F Toldrá, F (eds) The Encyclopedia of Food and Health 1 (2016): 401-406.

Trish Shea RD

Net Orders Checkout

Item Price Qty Total
Subtotal $0.00

Shipping Address

Shipping Methods